Telmisartan, when compared to losartan, shows additional beneficial effects to pancreatic islet structure and function in diet-induced obese mice

Materials and methods C57BL/6 mice were fed a standard chow (SC; 10% lipids) or a high-fat diet (HF; 50% lipids) for 10 weeks. Then, animals were randomly allocated into six groups to start the treatment with Telmisartan (T) or Losartan (L): SC, SC-L, SC-T, HF, HF-L and HF-T. The treatment phase lasted 5 weeks. Pair feeding (PF) groups were carried out to telmisartan treated groups (SCT-PF and HFT-PF) so as to isolate the effects of the treatment from the effects of reduced diet intake upon the evaluated parameters. Differences among the groups were tested with One-way ANOVA and Holm-Sidak post hoc test (P<0.05).